ÿþ<! DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0//EN"> <HTML> <TITLE> 35=BAB2> ?> 5:0@AB20<. >2>AB8 </TITLE> <meta http-equiv="Content-Type" content="text/html; charset=windows-1251"> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <meta name="keywords" content="Agencia Medicamentului, medicina, farmacia, medicamentul, controlul, autorizarea, 35=BAB2> ?> ;5:0@AB20<"> <BODY style="background-image:url('images2/fon5.bmp'); background-repeat: repeat;" LEFTMARGIN="4" TOPMARGIN="4" MARGINWIDTH="4" MARGINHEIGHT="4" > <TABLE style="border: 1px; text-align:center; font-size: 12px; font-family: Verdana;" width="760" cellpadding="0" cellspacing="0" > <tr> <td height=30 style='font-weight: bold;'> <img src='flag_ru.gif' border=1 align=left> <br> 35=BAB2> ?> ;5:0@AB20< ?@54;0305B D0@<0F52B8G5A:8< D8@<0< A;54CNI85 284K CA;C3 ?> 87CG5=8N 18>4>ABC?=>AB8 <i>in vitro </i> B25@4KE ;5:0@AB25==KE D>@<: <br><br> </td> <td height=30 style='font-weight: bold; cellpadding: 5px;'> <img src='flag_en.gif' border=1 align=right> <br> The Medicine Agency proposes to pharmaceutical manufactures to perform a range of services regarding Biodisponibility <i>in vitro </i>for solid dosage forms: <br><br> </td> </tr> <tr> <td height=30 style='font-size: 12px;'> <i> ;O ?@>872>48<KE 8 8<?>@B8@C5<KE ;5:0@AB25==KE ?@5?0@0B>2: </i> </td> <td height=30 style='font-size: 12px;'> <i> For dosage forms of local production and imported: </i> </td> </tr> <tr> <td style='font-size: 12px; text-align: left;'> <ul type=disc> <li> F5=:0 18>M:2820;5=B=>AB8 35=5@8G5A:8E ?@5?0@0B>2 ?> @57C;LB0B0< A@02=8B5;L=>3> B5AB0 @0AB2>@5=8O; </li> <li> ?@545;5=85 2=CB@8A5@89=>9 8 <56A5@89=>9 2>A?@>872>48<>AB8 ?0@0<5B@>2 18>4>ABC?=>AB8 2 :>=B5:AB5 20;840F88 B5E=>;>38G5A:>3> ?@>F5AA0;</li> <li> 7CG5=85 AB018;L=>AB8 ?0@0<5B@>2 18>4>ABC?=>AB8 2 ?@>F5AA5 E@0=5=8O ;5:0@AB25==KE ?@5?0@0B>2; </li> <li> KO2;5=85 :>=B@0D0:B=>9 ?@>4C:F88 =0 >A=>20=88 @07;8G8O ?@>D8;59 @0AB2>@5=8O.</li> </ul> </td> <td style='font-size: 12px; text-align: left;'> <ul type=disc> <li> Bioechivalence of generic drugs according to comparative test of dissolution; </li> <li> Reproductibility of biodisponibility parameters in- and among- batches for the validation of technological process; </li> <li> Stability study of biodisponibility parameters during storing of dosage forms; </li> <li> The elucidation of falsificated production based on the differences in dissolution profile. </li> </ul> </td> </tr> <tr> <td height=30 style='font-size: 12px;'> <i> ;O @07@010BK205<KE 8 3>B>2OI8EAO : ?@>872>4AB2C ;5:0@AB25==KE ?@5?0@0B>2:</i> </td> <td height=30 style='font-size: 12px;'> <i> For dosage forms during the elaboration and practical implementation:</i> </td> </tr> <tr> <td style='font-size: 12px; text-align: left;'> <ul type=disc> <li> ><>IL 2 >?B8<870F88 A>AB020 ;5:0@AB25==KE D>@< 8 ?0@0<5B@>2 B5E=>;>38G5A:8E ?@>F5AA>2 A F5;LN 4>AB865=8O =5>1E>48<>9 18>4>ABC?=>AB8; </li> <li> ?B8<870F8O CA;>289 2K?>;=5=8O B5AB0 @0AB2>@5=8O 4;O 2:;NG5=8O 2 =>@<0B82=>-0=0;8B8G5A:CN 4>:C<5=B0F8N; </li> <li> @>3=>78@>20=85 D0@<0:>:8=5B8G5A:8E ?@>D8;59 ;5:0@AB25==KE D>@< A <>48D8F8@>20==K< 2KA2>1>645=85< ?> @57C;LB0B0< B5AB0 @0AB2>@5=8O. </li> </ul> </td> <td style='font-size: 12px; text-align: left;'> <ul type=disc> <li> Optimization of dosage forms composition and parameters of technological process in order to achieve the required biodisponibility;</li> <li> Optimization of condition to performe dissolution test in order to introduce it in analytico-normative documentation;</li> <li> Prognosis of pharmacokinetic profiles of pharmaceutical forms modified release dosage forms based on dissolution test results. </li> </ul> </td> </tr> <tr> <td style='text-align: left;'> <br><b>;O A?@02>::</b> </td> <td style='text-align: left;'> <br><b>For information:</b> </td> </tr> <tr> <td style='text-align: left;'> <br><b>Te;/D0:A: </b> 73-70-45 <br><b><a href="mailto:valicavlad@yahoo.com" style="color: navy;"> </b> valicavlad@yahoo.com </a>, <a href="mailto:office@amed.md" style="color: navy;">office@amed.md</a> </td> <td style='text-align: left;'> <br><b>Tel/fax: </b> 73-70-45 <br><b><a href="mailto:valicavlad@yahoo.com" style="color: navy;"> </b> valicavlad@yahoo.com </a>, <a href="mailto:office@amed.md" style="color: navy;">office@amed.md</a> </td> </tr> </TABLE> </body> </html>